EFS may refer to one of the following:
- Electronic Filing System, an electronic platform by the Singapore Judiciary
- Electronic Filing System, an electronic platform for the United States Patent & Trademark office
- Emergency Fire Service, now Country Fire Service (Australia)
- Emperor of the Fading Suns, a turn-based, strategy video-game
- Encrypting File System, the encryption subsystem of the NTFS file system
- Extent File System, a file system used in the IRIX operating system
- Estrada de Ferro Sorocabana, a Brazilian railway
- Event free survival, measure of cancer in medicine.
- Exchange of Futures for Swaps
- EFS, a Portuguese manufacturer of lightweight motorcycles
- Ethnological Forgery Series (E.F.S), a series of songs by the krautrock band Can
- Escape from Samsara, a London based nightclub
- EF-S, a derivative of Canon's EF lens mount
- Swedish Evangelical Mission, abbreviated EFS (Evangeliska fosterlandsstiftelsen in Swedish)
- Endian Firewall System, an open source firewall system
- Expenditure and Food Survey, a statistical survey conducted annually by the Office for National Statistics in Great Britain
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